Dynamics of N6-methyladenosine modification during Alzheimer's disease development.

ABSTRACT: N6-methyladenosine (m6A) modification is a common RNA modification in the central nervous system and has been linked to various neurological disorders, including Alzheimer's disease (AD). However, the dynamic of mRNA m6A modification and m6A enzymes during the development of AD are not well understood. Therefore, this study examined the expression profiles of m6A and its enzymes in the development of AD. The results showed that changes in the expression levels of m6A regulatory factors occur in the early stages of AD, indicating a potential role for m6A modification in the onset of the disease. Additionally, the analysis of mRNA m6A expression profiles using m6A-seq revealed significant differences in m6A modification between AD and control brains. The genes with differential methylation w

SUBMITTER: Gao S 

PROVIDER: S-EPMC10944207 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature