A novel role for phospholamban in the thalamic reticular nucleus.

ABSTRACT: The thalamic reticular nucleus (TRN) is a brain region that influences vital neurobehavioral processes, including executive functioning and the generation of sleep rhythms. TRN dysfunction underlies hyperactivity, attention deficits, and sleep disturbances observed across various neurodevelopmental disorders. A specialized sarco-endoplasmic reticulum calcium (Ca²⁺) ATPase 2 (SERCA2)-dependent Ca²⁺ signaling network operates in the dendrites of TRN neurons to regulate their bursting activity. Phospholamban (PLN) is a prominent regulator of SERCA2 with an established role in myocardial Ca²⁺-cycling. Our findings suggest that the role of PLN extends beyond the cardiovascular system to impact brain function. Specifically, we found PLN to be expressed

SUBMITTER: Klocke B 

PROVIDER: S-EPMC10944534 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature