Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors.
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ABSTRACT: Background
The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences.Methods
A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking.Results
Here we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers.Conclusion
This study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.
SUBMITTER: Kjerulff B
PROVIDER: S-EPMC10944541 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Publications
Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors.
Kjerulff Bertram B Dowsett Joseph J Jacobsen Rikke Louise RL Gladov Josephine J Larsen Margit Hørup MH Lundgaard Agnete Troen AT Banasik Karina K Westergaard David D Mikkelsen Susan S Dinh Khoa Manh KM Hindhede Lotte L Kaspersen Kathrine Agergård KA Schwinn Michael M Juul Anders A Poulsen Betina B Lindegaard Birgitte B Pedersen Carsten Bøcker CB Sabel Clive Eric CE Bundgaard Henning H Nielsen Henriette Svarre HS Møller Janne Amstrup JA Boldsen Jens Kjærgaard JK Burgdorf Kristoffer Sølvsten KS Kessing Lars Vedel LV Handgaard Linda Jenny LJ Thørner Lise Wegner LW Didriksen Maria M Nyegaard Mette M Grarup Niels N Ødum Niels N Johansson Pär I PI Jennum Poul P Frikke-Schmidt Ruth R Berger Sanne Schou SS Brunak Søren S Jacobsen Søren S Hansen Thomas Folkmann TF Lundquist Tine Kirkeskov TK Hansen Torben T Sørensen Torben Lykke TL Sigsgaard Torben T Nielsen Kaspar René KR Bruun Mie Topholm MT Hjalgrim Henrik H Ullum Henrik H Rostgaard Klaus K Sørensen Erik E Pedersen Ole Birger OB Ostrowski Sisse Rye SR Erikstrup Christian C
Communications medicine 20240316 1
<h4>Background</h4>The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences.<h4>Methods</h4>A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using reg ...[more]
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