FusionNW, a potential clinical impact assessment of kinases in pan-cancer fusion gene network.

ABSTRACT: Kinase fusion genes are the most active fusion gene group in human cancer fusion genes. To help choose the clinically significant kinase so that the cancer patients that have fusion genes can be better diagnosed, we need a metric to infer the assessment of kinases in pan-cancer fusion genes rather than relying on the sample frequency expressed fusion genes. Most of all, multiple studies assessed human kinases as the drug targets using multiple types of genomic and clinical information, but none used the kinase fusion genes in their study. The assessment studies of kinase without kinase fusion gene events can miss the effect of one of the mechanisms that enhance the kinase function in cancer. To fill this gap, in this study, we suggest a novel way of assessing genes using a network propagat

SUBMITTER: Yang C 

PROVIDER: S-EPMC10944571 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature