DeTox: a pipeline for the detection of toxins in venomous organisms.

ABSTRACT: Venomous organisms have independently evolved the ability to produce toxins 101 times during their evolutionary history, resulting in over 200 000 venomous species. Collectively, these species produce millions of toxins, making them a valuable resource for bioprospecting and understanding the evolutionary mechanisms underlying genetic diversification. RNA-seq is the preferred method for characterizing toxin repertoires, but the analysis of the resulting data remains challenging. While early approaches relied on similarity-based mapping to known toxin databases, recent studies have highlighted the importance of structural features for toxin detection. The few existing pipelines lack an integration between these complementary approaches, and tend to be difficult to run for non-experienced us

SUBMITTER: Ringeval A 

PROVIDER: S-EPMC10944572 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature