Serum electrolyte concentrations and risk of atrial fibrillation: an observational and mendelian randomization study.

ABSTRACT:

Background

Atrial fibrillation (AF) is a prevalent arrhythmic condition resulting in increased stroke risk and is associated with high mortality. Electrolyte imbalance can increase the risk of AF, where the relationship between AF and serum electrolytes remains unclear.

Methods

A total of 15,792 individuals were included in the observational study, with incident AF ascertainment in the Atherosclerosis Risk in Communities (ARIC) study. The Cox regression models were applied to calculate the hazard ratio (HR) and 95% confidence interval (CI) for AF based on different serum electrolyte levels. Mendelian randomization (MR) analyses were performed to examine the causal association.

Results

In observational study, after a median 19.7 years of follow-up, a total of 2551 deve

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10944597 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature