Bioinformatics analysis of the prognostic role of alternative splicing data in lung adenocarcinoma.

ABSTRACT:

Background

As a post-transcriptional regulatory mechanism, alternative splicing (AS) is engaged in a variety of pathophysiological processes, and it has been widely reported in connection with the occurrence, progression, metastasis, and drug resistance of cancer. However, the research on AS in lung adenocarcinoma (LUAD) is very limited. In addition, the prognostic effect of AS event (ASE) on LUAD and its related mechanism are not clear. This study aimed to explore the role and potential prognostic value of ASE in LUAD.

Methods

Relevant data and ASE datasets of the sample were acquired from The Cancer Genome Atlas (TCGA) and TCGASpliceSeq databases. We constructed a new prognostic criterion based on ASEs. Then, Cox regression and least absolute shrinkage and selection operat

SUBMITTER: Zhao L 

PROVIDER: S-EPMC10944774 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature