Differential response to roflumilast in patients with chronic obstructive pulmonary disease: real-world evidence.

ABSTRACT:

Background

Roflumilast is effective in reducing acute exacerbation in patients with chronic obstructive pulmonary disease (COPD) at high risk of severe exacerbation. Clinical traits related to the benefits of roflumilast need to be evaluated in patients with COPD.

Methods

A longitudinal observational study in patients newly diagnosed with COPD was conducted using claims data from the Health Insurance Review and Assessment Service in South Korea from 2012-2020 after a 2-year washout period. The primary outcome was to estimate the ratio of hazard ratio (RHR) of roflumilast for moderate-to-severe exacerbation in prespecified subgroups. A time-dependent Cox regression model was used to estimate the hazard ratio (HR) for moderate-to-severe exacerbations.

Results

Among 823,

SUBMITTER: Lee HW 

PROVIDER: S-EPMC10944795 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature