PANoptosis-related genes function as efficient prognostic biomarkers in colon adenocarcinoma.

ABSTRACT:

Background

PANoptosis is a newly discovered cell death type, and tightly associated with immune system activities. To date, the mechanism, regulation and application of PANoptosis in tumor is largely unknown. Our aim is to explore the prognostic value of PANoptosis-related genes in colon adenocarcinoma (COAD).

Methods

Analyzing data from The Cancer Genome Atlas-COAD (TCGA-COAD) involving 458 COAD cases, we concentrated on five PANoptosis pathways from the Molecular Signatures Database (MSigDB) and a comprehensive set of immune-related genes. Our approach involved identifying distinct genetic COAD subtype clusters and developing a prognostic model based on these parameters.

Results

The research successfully identified two genetic subtype clusters in COAD, marked by dis

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10944899 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature