High lymphocyte signature genes expression in parathyroid endocrine cells and its downregulation linked to tumorigenesis.

ABSTRACT:

Background

To date, because of the difficulty in obtaining normal parathyroid gland samples in human or in animal models, our understanding of this last-discovered organ remains limited.

Methods

In the present study, we performed a single-cell transcriptome analysis of six normal parathyroid and eight parathyroid adenoma samples using 10 × Genomics platform.

Findings

We have provided a detailed expression atlas of parathyroid endocrine cells. Interestingly, we found an exceptional high expression levels of CD4 and CD226 in parathyroid endocrine cells, which were even higher than those in lymphocytes. This unusual expression of lymphocyte markers in parathyroid endocrine cells was associated with the depletion of CD4 T cells in normal parathyroid glands. Moreover, CD4

SUBMITTER: Geng C 

PROVIDER: S-EPMC10945207 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature