E3 ubiquitin ligase rififylin has yin and yang effects on rabbit cardiac transient outward potassium currents (I_to) and corresponding channel proteins.

ABSTRACT: Genome-wide association studies have reported a correlation between a SNP of the RING finger E3 ubiquitin protein ligase rififylin (RFFL) and QT interval variability in humans (Newton-Cheh et al., 2009). Previously, we have shown that RFFL downregulates expression and function of the human-like ether-a-go-go-related gene potassium channel and corresponding rapidly activating delayed rectifier potassium current (I_Kr) in adult rabbit ventricular cardiomyocytes. Here, we report that RFFL also affects the transient outward current (I_to), but in a peculiar way. RFFL overexpression in adult rabbit ventricular cardiomyocytes significantly decreases the contribution of its fast component (I_to,f) from 35% to 21% and increases the contribution of its slow component (

SUBMITTER: Kabakov AY 

PROVIDER: S-EPMC10945274 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature