Orai-mediated calcium entry determines activity of central dopaminergic neurons by regulation of gene expression.

ABSTRACT: Maturation and fine-tuning of neural circuits frequently require neuromodulatory signals that set the excitability threshold, neuronal connectivity, and synaptic strength. Here, we present a mechanistic study of how neuromodulator-stimulated intracellular Ca²⁺ signals, through the store-operated Ca²⁺ channel Orai, regulate intrinsic neuronal properties by control of developmental gene expression in flight-promoting central dopaminergic neurons (fpDANs). The fpDANs receive cholinergic inputs for release of dopamine at a central brain tripartite synapse that sustains flight (Sharma and Hasan, 2020). Cholinergic inputs act on the muscarinic acetylcholine receptor to stimulate intracellular Ca²⁺ release through the endoplasmic reticulum (ER) localised inositol

SUBMITTER: Mitra R 

PROVIDER: S-EPMC10945566 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature