Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues.

ABSTRACT: Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes to many human diseases. Given that circulating bioactive factors are stable in serum, occur naturally, and are easily assayed from blood, they present obvious focal molecules for therapeutic intervention and biomarker development. Recently, studies have shown that secreted proteins mediating inter-tissue signaling could be identified by 'brute force' surveys of all genes within RNA-sequencing measures across tissues within a population. Expanding on this intuition, we reasoned that parallel strategies could be used to understand how individual genes mediate signaling across metabolic tissues through correlative analyses of gene variation between individuals. Thus, comparison

SUBMITTER: Zhou M 

PROVIDER: S-EPMC10945578 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature