Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling.

ABSTRACT: While physiologic stress has long been known to impair mammalian reproductive capacity through hormonal dysregulation, mounting evidence now suggests that stress experienced prior to or during gestation may also negatively impact the health of future offspring. Rodent models of gestational physiologic stress can induce neurologic and behavioral changes that persist for up to three generations, suggesting that stress signals can induce lasting epigenetic changes in the germline. Treatment with glucocorticoid stress hormones is sufficient to recapitulate the transgenerational changes seen in physiologic stress models. These hormones are known to bind and activate the glucocorticoid receptor (GR), a ligand-inducible transcription factor, thus implicating GR-mediated signaling as a potential c

SUBMITTER: Cincotta SA 

PROVIDER: S-EPMC10945581 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature