A system of feed-forward cerebellar circuits that extend and diversify sensory signaling.

ABSTRACT: Sensory signals are processed by the cerebellum to coordinate movements. Numerous cerebellar functions are thought to require the maintenance of a sensory representation that extends beyond the input signal. Granule cells receive sensory input, but they do not prolong the signal and are thus unlikely to maintain a sensory representation for much longer than the inputs themselves. Unipolar brush cells (UBCs) are excitatory interneurons that project to granule cells and transform sensory input into prolonged increases or decreases in firing, depending on their ON or OFF UBC subtype. Further extension and diversification of the input signal could be produced by UBCs that project to one another, but whether this circuitry exists is unclear. Here we test whether UBCs innervate one another and e

SUBMITTER: Hariani HN 

PROVIDER: S-EPMC10945699 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature