The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota.

ABSTRACT: The somatosensory nervous system surveils external stimuli at barrier tissues, regulating innate immune cells under infection and inflammation. The roles of sensory neurons in controlling the adaptive immune system, and more specifically immunity to the microbiota, however, remain elusive. Here, we identified a mechanism for direct neuroimmune communication between commensal-specific T lymphocytes and somatosensory neurons mediated by the neuropeptide calcitonin gene-related peptide (CGRP) in the skin. Intravital imaging revealed that commensal-specific T cells are in close proximity to cutaneous nerve fibers in vivo. Correspondingly, we observed upregulation of the receptor for the neuropeptide CGRP, RAMP1, in CD8⁺ T lymphocytes induced by skin commensal colonization. The neuro

SUBMITTER: Kulalert W 

PROVIDER: S-EPMC10945812 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature