Influence of angiotensin receptor-neprilysin inhibition on the efficacy of Empagliflozin on cardiac structure and function in patients with chronic heart failure and a reduced ejection fraction: The Empire HF trial.

ABSTRACT:

Study objective

The objective was to assess the effect of ongoing angiotensin receptor-neprilysin inhibitor(ARNI) on the effect of the sodium glucose cotransporter 2 (SGLT2) inhibitor empagliflozin on left ventricular (LV) size and function in patients with heart failure and reduced ejection fraction(HFrEF).

Design

Post hoc analysis of the Empire HF trial, an investigator-initiated, double-blind, randomized controlled trial.

Participants

190 patients with HFrEF with New York Heart association class I-III symptoms with an ejection fraction of 40 % or below. Patients were stratified according to ongoing ARNI treatment at baseline.

Intervention

Empagliflozin 10 mg daily or placebo for 12 weeks. Echocardiography at baseline and follow-up.

Main outcome measures</

SUBMITTER: Larsen JH 

PROVIDER: S-EPMC10946004 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature