Oncostatin M mediates cardioprotection via angiogenesis in ischemic heart disease.

ABSTRACT:

Objective

Oncostatin M (OSM) is an inflammatory cytokine belonging to the interleukin-6 family member, which plays an important role in various cardiovascular diseases. We recently reported increased serum OSM levels in patients with coronary artery disease. However, the specific role in HF with ischemic heart disease (IHD) remains unclear.

Methods and results

A total of 120 patients with HF and 48 control subjects were enrolled in this study. Serum OSM levels were measured using a sandwich technique immunoassay during the compensated state. The results revealed significantly higher serum OSM levels in HF patients compared to controls. Importantly, HF patients with IHD had higher OSM levels, and those with collateral flow showed the even higher levels, indicating a potential

SUBMITTER: Ikeda S 

PROVIDER: S-EPMC10946052 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature