Association of sildenafil use with age-related macular degeneration: a retrospective cohort study.

ABSTRACT:

Objective

Despite significant advances in clinical care and understanding of the underlying pathophysiology, age-related macular degeneration (AMD)-a major cause of global blindness-lacks effective treatment to prevent the irreversible degeneration of photoreceptors leading to central vision loss. Limited studies suggest phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil, may prevent AMD by increasing retinal blood flow. This study explores the potential association between sildenafil use and AMD risk in men with erectile dysfunction using UK data.

Methods and analysis

Using the UK's IQVIA Medical Research Data, the study analysed 31 575 men prescribed sildenafil for erectile dysfunction and no AMD history from 2007 to 2015, matched with a comparator group of 62

SUBMITTER: Han JED 

PROVIDER: S-EPMC10946355 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature