Establishing causal relationships between sleep and adiposity traits using Mendelian randomization.

ABSTRACT:

Objective

The aim of this study was to systematically evaluate the direction of any potential causal effect between sleep and adiposity traits.

Methods

Two-sample Mendelian randomization was used to assess the association of genetically predicted sleep traits with adiposity and vice versa. Using data from UK Biobank and 23andMe, the sleep traits explored were morning preference (chronotype; N = 697,828), insomnia (N = 1,331,010), sleep duration (N = 446,118), napping (N = 452,633), and daytime sleepiness (N = 452,071). Using data from the Genetic Investigation of ANthropometric Traits (GIANT) and Early Growth Genetics (EGG) consortia, the adiposity traits explored were adult BMI, hip circumference (HC), waist circumference (WC), waist-hip ratio (WHR; N = 322,154), and childh

SUBMITTER: Hayes BL 

PROVIDER: S-EPMC10946465 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature