Ontology highlight
ABSTRACT:
SUBMITTER: Griffiths RC
PROVIDER: S-EPMC10946470 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Griffiths Rhys C RC Smith Frances R FR Li Diyuan D Wyatt Jasmine J Rogers David M DM Long Jed E JE Cusin Lola M L LML Tighe Patrick J PJ Layfield Robert R Hirst Jonathan D JD Müller Manuel M MM Mitchell Nicholas J NJ
Chemistry (Weinheim an der Bergstrasse, Germany) 20230214 16
The site-selective modification of peptides and proteins facilitates the preparation of targeted therapeutic agents and tools to interrogate biochemical pathways. Among the numerous bioconjugation techniques developed to install groups of interest, those that generate C(sp<sup>3</sup> )-C(sp<sup>3</sup> ) bonds are significantly underrepresented despite affording proteolytically stable, biogenic linkages. Herein, a visible-light-mediated reaction is described that enables the site-selective modi ...[more]