Does the microbiome play a role in the pathogenesis of colonic diverticular disease? A systematic review.

ABSTRACT:

Background and aims

The role of the microbiota in diverticulosis and diverticular disease is underexplored. This systematic review aimed to assess all literature pertaining to the microbiota and metabolome associations in asymptomatic diverticulosis, symptomatic uncomplicated diverticular disease (SUDD), and diverticulitis pathophysiology.

Methods

Seven databases were searched for relevant studies published up to September 28, 2022. Data were screened in Covidence and extracted to Excel. Critical appraisal was undertaken using the Newcastle Ottawa Scale for case/control studies.

Results

Of the 413 papers screened by title and abstract, 48 full-text papers were reviewed in detail with 12 studies meeting the inclusion criteria. Overall, alpha and beta diversity were unc

SUBMITTER: Cameron R 

PROVIDER: S-EPMC10946483 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature