Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress.

ABSTRACT: The hippocampal CA2 region has received greater attention in recent years due to its fundamental role in social memory and hippocampus-dependent memory processing. Unlike entorhinal cortical inputs, the Schaffer collateral inputs to CA2 do not support activity-dependent long-term potentiation (LTP), which serves as the basis for long-term memories. This LTP-resistant zone also expresses genes that restrict plasticity. With the aim of exploring social interaction and sociability in rats that were subjected to juvenile stress, we addressed questions about how the neural circuitry is altered and its effects on social behavior. Although there was induction of LTP in both Schaffer collateral and entorhinal cortical pathways in juvenile-stressed rats, LTP declined in both pathways after 2-3 h. M

SUBMITTER: Raghuraman R 

PROVIDER: S-EPMC10946601 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature