Variability of the response to immunotherapy among subgroups of patients with multiple sclerosis.

ABSTRACT:

Background and purpose

This study assessed the effect of patient characteristics on the response to disease-modifying therapy (DMT) in multiple sclerosis (MS).

Methods

We extracted data from 61,810 patients from 135 centers across 35 countries from the MSBase registry. The selection criteria were: clinically isolated syndrome or definite MS, follow-up ≥ 1 year, and Expanded Disability Status Scale (EDSS) score ≥ 3, with ≥1 score recorded per year. Marginal structural models with interaction terms were used to compare the hazards of 12-month confirmed worsening and improvement of disability, and the incidence of relapses between treated and untreated patients stratified by their characteristics.

Results

Among 24,344 patients with relapsing MS, those on DMTs experienced

SUBMITTER: Diouf I 

PROVIDER: S-EPMC10946605 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature