Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation.
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ABSTRACT:
SUBMITTER: Chawda MM
PROVIDER: S-EPMC10946610 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
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Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation.
Chawda Mira M MM Ross Susan S Lau Ching-In CI Yánez Diana C DC Rowell Jasmine J Kilbride Peter P Crompton Tessa T
European journal of immunology 20231017 12
Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outcome. Thus, cryopreservation of thymus may improve outcomes in thymus transplant patients. ...[more]
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