Deletion of NRF2 disturbs composition, morphology, and differentiation of the murine tail epidermis in chronological aging.

ABSTRACT: NRF2 is a master regulator of the cellular protection against oxidative damage in mammals and of multiple pathways relevant in the mammalian aging process. In the epidermis of the skin NRF2 contributes additionally to the formation of an antioxidant barrier to protect from environmental insults and is involved in the differentiation process of keratinocytes. In chronological aging of skin, the capacity for antioxidant responses and the ability to restore homeostasis after damage are impaired. Surprisingly, in absence of extrinsic stressors, NRF2 deficient mice do not show any obvious skin phenotype, not even at old age. We investigated the differences in chronological epidermal aging of wild type and NRF2-deficient mice to identify the changes in aged epidermis that may compensate for abse

SUBMITTER: Sochorova M 

PROVIDER: S-EPMC10946746 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature