Quantification of Prostate Cancer Metabolism Using 3D Multiecho bSSFP and Hyperpolarized [1-¹³ C] Pyruvate: Metabolism Differs Between Tumors of the Same Gleason Grade.

ABSTRACT:

Background

Three-dimensional (3D) multiecho balanced steady-state free precession (ME-bSSFP) has previously been demonstrated in preclinical hyperpolarized (HP) ¹³ C-MRI in vivo experiments, and it may be suitable for clinical metabolic imaging of prostate cancer (PCa).

Purpose

To validate a signal simulation framework for the use of sequence parameter optimization. To demonstrate the feasibility of ME-bSSFP for HP ¹³ C-MRI in patients. To evaluate the metabolism in PCa measured by ME-bSSFP.

Study type

Retrospective single-center cohort study.

Phantoms/population

Phantoms containing aqueous solutions of [1-¹³ C] lactate (2.3 M) and [¹³ C] urea (8 M). Eight patients (mean age 67 ± 6 years) with biopsy-confirmed Gleason

SUBMITTER: Chowdhury R 

PROVIDER: S-EPMC10946772 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature