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ABSTRACT:
SUBMITTER: Houszka N
PROVIDER: S-EPMC10946812 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Houszka Nicole N Mikula Hannes H Svatunek Dennis D
Chemistry (Weinheim an der Bergstrasse, Germany) 20230413 29
1,2,4,5-Tetrazines are increasingly used as reactants in bioorthogonal chemistry due to their high reactivity in Diels-Alder reactions with various dienophiles. Substituents in the 3- and 6-positions of the tetrazine scaffold are known to have a significant impact on the rate of cycloadditions; this is commonly explained on the basis of frontier molecular orbital theory. In contrast, we show that reactivity differences between commonly used classes of tetrazines are not controlled by frontier mo ...[more]