Selective perforant-pathway atrophy in Huntington disease: MRI analysis of hippocampal subfields.

ABSTRACT:

Introduction

While individuals with Huntington disease (HD) show memory impairment that indicates hippocampal dysfunction, the available literature does not consistently identify structural evidence for involvement of the whole hippocampus but rather suggests that hippocampal atrophy may be confined to certain hippocampal subregions.

Methods

We processed T1-weighted MRI from IMAGE-HD study using FreeSurfer 7.0 and compared the volumes of the hippocampal subfields among 36 early motor symptomatic (symp-HD), 40 pre-symptomatic (pre-HD), and 36 healthy control individuals across three timepoints over 36 months.

Results

Mixed-model analyses revealed significantly lower subfield volumes in symp-HD, compared with pre-HD and control groups, in the subicular regions of the pe

SUBMITTER: Wibawa P 

PROVIDER: S-EPMC10946817 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature