FasL is a catabolic factor in alveolar bone homeostasis.

ABSTRACT:

Aim

Fas ligand (FasL) belongs to the tumour necrosis factor superfamily regulating bone turnover, inflammation, and apoptosis. The appendicular and axial skeleton phenotype of mature Fasl^gld mice has been reported. The impact of FasL on the alveolar bone providing support for the teeth at mature stages under healthy and induced inflammatory conditions remains unknown.

Materials and methods

We performed a phenotypical analysis of mice carrying the homozygous Fasl^gld mutation and wild-type (WT) mice (C57BL/6) under healthy conditions and upon ligature-induced periodontitis. After 12 days, micro-computed tomography analysis revealed the distance between the cement enamel junction and the alveolar bone crest. Additional structural parameters, such as the bo

SUBMITTER: Apaza Alccayhuaman KA 

PROVIDER: S-EPMC10946845 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature