Dynamic fronto-amygdalar interactions underlying emotion-regulation deficits in women at higher weight.

ABSTRACT:

Objective

The regulation of negative emotions entails the modulation of subcortical regions, such as the amygdala, by prefrontal regions. There is preliminary evidence suggesting that individuals at higher weight may present with hypoactivity in prefrontal regulatory systems during emotional regulation, although the directionality of these pathways has not been tested. In this study, we compared fronto-amygdalar effective connectivity during cognitive reappraisal as a function of BMI in 48 adult women with obesity and 54 control participants.

Methods

Dynamic causal modeling and parametric empirical Bayes were used to map effective connectivity between the dorsomedial prefrontal cortex, orbitofrontal cortex, dorsolateral prefrontal cortex, and the amygdala.

Results

Dif

SUBMITTER: Maturana-Quijada P 

PROVIDER: S-EPMC10946850 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature