Use of a gene expression signature to identify trimetazidine for repurposing to treat bipolar depression.

ABSTRACT:

Objectives

The aim of this study was to repurpose a drug for the treatment of bipolar depression.

Methods

A gene expression signature representing the overall transcriptomic effects of a cocktail of drugs widely prescribed to treat bipolar disorder was generated using human neuronal-like (NT2-N) cells. A compound library of 960 approved, off-patent drugs were then screened to identify those drugs that affect transcription most similar to the effects of the bipolar depression drug cocktail. For mechanistic studies, peripheral blood mononuclear cells were obtained from a healthy subject and reprogrammed into induced pluripotent stem cells, which were then differentiated into co-cultured neurons and astrocytes. Efficacy studies were conducted in two animal models of depressive-

SUBMITTER: Bortolasci CC 

PROVIDER: S-EPMC10946906 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature