From Chemotherapy to Phototherapy - Changing the Therapeutic Action of a Metallo-Intercalating Ru^II -Re^I Luminescent System by Switching its Sub-Cellular Location.

ABSTRACT: The synthesis of a new heterodinuclear Re^I Ru^II metallointercalator containing Ru^II (dppz) and Re^I (dppn) moieties is reported. Cell-free studies reveal that the complex has similar photophysical properties to its homoleptic M(dppz) analogue and it also binds to DNA with a similar affinity. However, the newly reported complex has very different in-cell properties to its parent. In complete contrast to the homoleptic system, the Ru^II (dppz)/Re^I (dppn) complex is not intrinsically cytotoxic but displays appreciable phototoxic, despite both complexes displaying very similar quantum yields for singlet oxygen sensitization. Optical microscopy suggests that the reason for these contrasting biological effects is that whereas the ho

SUBMITTER: Saeed HK 

PROVIDER: S-EPMC10946911 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature