Engineered Binding Microenvironments in Halogen Bonding Polymers for Enhanced Anion Sensing.

ABSTRACT: Mimicking Nature's polymeric protein architectures by designing hosts with binding cavities screened from bulk solvent is a promising approach to achieving anion recognition in competitive media. Accomplishing this, however, can be synthetically demanding. Herein we present a synthetically tractable approach, by directly incorporating potent supramolecular anion-receptive motifs into a polymeric scaffold, tuneable through a judicious selection of the co-monomer. A comprehensive analysis of anion recognition and sensing is demonstrated with redox-active, halogen bonding polymeric hosts. Notably, the polymeric hosts consistently outperform their monomeric analogues, with especially large halide binding enhancements of ca. 50-fold observed in aqueous-organic solvent mixtures. These binding en

SUBMITTER: Bak KM 

PROVIDER: S-EPMC10946961 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature