Increased mucosal eosinophils in colonic diverticulosis and diverticular disease.

ABSTRACT:

Aims

Eosinophils contribute to tissue homeostasis, damage, and repair. The mucosa of colonic diverticula has not been evaluated for eosinophils by quantitative histology. We aimed to investigate whether mucosal eosinophils and other immune cells are increased in colonic diverticula.

Methods

Hematoxylin and eosin stained sections from colonic surgical resections (n = 82) containing diverticula were examined. Eosinophils, neutrophils, and lymphocytes, in five high power fields in the lamina propria were counted at the base, neck, and ostia of the diverticulum and counts compared to non-diverticula mucosa. The cohort was further subgrouped by elective and emergency surgical indications.

Results

Following an initial review of 10 surgical resections from patients with dive

SUBMITTER: Cameron R 

PROVIDER: S-EPMC10946982 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature