Longitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [¹¹ C]UCB-J Positron Emission Tomography Study.

ABSTRACT:

Background

Synaptic loss is characteristic of many neurodegenerative diseases; it occurs early and is strongly related to functional deficits.

Objective

In this longitudinal observational study, we determine the rate at which synaptic density is reduced in the primary tauopathies of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and we test the relationship with disease progression.

Methods

Our cross-sectional cohort included 32 participants with probable PSP and 16 with probable CBD (all amyloid-negative corticobasal syndrome), recruited from tertiary care centers in the United Kingdom, and 33 sex- and age-matched healthy control subjects. Synaptic density was estimated by positron emission tomography imaging with the radioligand [^11</

SUBMITTER: Holland N 

PROVIDER: S-EPMC10947001 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature