The association between atopic eczema and lymphopenia: Results from a UK cohort study with replication in US survey data.

ABSTRACT:

Background

Lymphocyte skin homing in atopic eczema (AE) may induce lymphopenia.

Objective

To determine if AE is associated with lymphopenia.

Methods

We used UK primary care electronic health records (Clinical Practice Research Datalink GOLD) for a matched cohort study in adults (18 years+) (1997-2015) with at least one recorded lymphocyte count. We matched people with AE to up to five people without. We used multivariable logistic regression to estimate the association between AE and lymphopenia (two low lymphocyte counts within 3 months) and linear mixed effects regression to estimate the association with absolute lymphocyte counts using all available counts. Cox proportional hazard models were used to investigate the effect of lymphopenia on common infections. We re

SUBMITTER: Hollestein LM 

PROVIDER: S-EPMC10947025 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature