Comparative proteomic analysis of tail regeneration in the green anole lizard, Anolis carolinensis.

ABSTRACT: As amniote vertebrates, lizards are the most closely related organisms to humans capable of appendage regeneration. Lizards can autotomize, or release their tails as a means of predator evasion, and subsequently regenerate a functional replacement. Green anoles (Anolis carolinensis) can regenerate their tails through a process that involves differential expression of hundreds of genes, which has previously been analyzed by transcriptomic and microRNA analysis. To investigate protein expression in regenerating tissue, we performed whole proteomic analysis of regenerating tail tip and base. This is the first proteomic data set available for any anole lizard. We identified a total of 2,646 proteins - 976 proteins only in the regenerating tail base, 796 only in the tail tip, and 874 in

SUBMITTER: Xu C 

PROVIDER: S-EPMC10947082 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature