Sleeve gastrectomy causes weight-loss independent improvements in hepatic steatosis.

ABSTRACT:

Background and aims

Sleeve gastrectomy (VSG) leads to improvement in hepatic steatosis, associated with weight loss. The aims of this study were to investigate whether VSG leads to weight-loss independent improvements in liver steatosis in mice with diet-induced obesity (DIO); and to metabolically and transcriptomically profile hepatic changes in mice undergoing VSG.

Methods

Mice with DIO were treated with VSG, sham surgery with subsequent food restriction to weight-match to the VSG group (Sham-WM), or sham surgery with return to unrestricted diet (Sham-Ad lib). Hepatic steatosis, glucose tolerance, insulin and glucagon resistance, and hepatic transcriptomics were investigated at the end of the study period and treatment groups were compared with mice undergoing sham surgery

SUBMITTER: McGlone ER 

PROVIDER: S-EPMC10947097 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature