Polygenic risk of obesity and BMI trajectories over 36 years: A longitudinal study of adult Finnish twins.

ABSTRACT:

Objective

This study investigated 36-year BMI trajectories in twins whose BMI in young adulthood was below, within, or above their genetically predicted BMI, with a focus on twin pairs with large intrapair BMI differences (within-pair ΔBMI ≥ 3 kg/m² ).

Methods

Together, 3227 like-sexed twin pairs (34% monozygotic) were examined at age ~30 years in 1975 and followed up in 1981, 1990, and 2011. An individual's observed BMI in 1975 was considered within (±2.0), below (<-2.0), or above (>+2.0) genetically predicted BMI, measured by a polygenic risk score of 996,919 single nucleotide polymorphisms.

Results

In monozygotic and dizygotic twin pairs with large intrapair BMI differences, the co-twin with a higher observed BMI in 1975 deviated above predicted BMI more

SUBMITTER: Berntzen BJ 

PROVIDER: S-EPMC10947257 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature