Paths to hippocampal damage in neuromyelitis optica spectrum disorders.

ABSTRACT:

Aims

Many patients with neuromyelitis optica spectrum disorders (NMOSD) suffer from cognitive impairment affecting memory, processing speed and attention and suffer from depressive symptoms. Because some of these manifestations could trace back to the hippocampus, several magnetic resonance imaging (MRI) studies have been performed in the past, with a number of groups describing volume loss of the hippocampus in NMOSD patients, whereas others did not observe such changes. Here, we addressed these discrepancies.

Methods

We performed pathological and MRI studies on the hippocampi of NMOSD patients, combined with detailed immunohistochemical analysis of hippocampi from experimental models of NMOSD.

Results

We identified different pathological scenarios for hippocampal da

SUBMITTER: Zakani M 

PROVIDER: S-EPMC10947283 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature