Subgingival microbial diversity and respiratory decline: A cross-sectional study.

ABSTRACT:

Aim

To investigate whether there is an association between subgingival microbial diversity and reduced respiratory function.

Materials and methods

A group of dentate 58-72-year-old men in Northern Ireland had a comprehensive periodontal examination including subgingival plaque sampling. DNA was extracted from plaque samples and the V1-V3 regions of the 16S rRNA gene were analysed by high-throughput sequencing and a microbial diversity index (MDI) was derived. Spirometry measurements were made using a wedge bellows spirometer. The primary outcome variable of interest was the percentage of predicted forced expiratory volume in 1 s (% predicted FEV₁ ). Analysis included multiple linear regression with adjustment for various confounders.

Results

Five-hundred an

SUBMITTER: Winning L 

PROVIDER: S-EPMC10947346 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature