Maternal intake of folate and folic acid during pregnancy and markers of male fecundity: A population-based cohort study.

ABSTRACT:

Background

Poor male fecundity is of concern, and a prenatal origin has been proposed. Folate, a methyl donor involved in DNA methylation, is essential for normal fetal development by regulating gene expression during different periods of fetal development. Thus, prenatal exposure to low maternal folate intake might have a programing function of the developing reproductive organs.

Objectives

To examine the association between maternal intake of folate from diet and folic acid from supplements during pregnancy and markers of fecundity in young men.

Materials and methods

We conducted a follow-up study using a Danish mother-son cohort of 787 young men born 1998-2000. Percentage differences in semen characteristics, testes volume, and reproductive hormone levels were anal

SUBMITTER: Gaml-Sorensen A 

PROVIDER: S-EPMC10947439 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature