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A Domino Radical Amidation/Semipinacol Approach to All-Carbon Quaternary Centers Bearing an Aminomethyl Group.

ABSTRACT: A photoredox-mediated radical amidation ring-expansion sequence that enables the generation of all-carbon quaternary centers bearing a protected aminomethyl substituent is described. The methodology can be applied to both styrene and unactivated alkene substrates generating structurally diverse sp3 -rich amine derivatives in a concise manner.

SUBMITTER: Dhak MS 

PROVIDER: S-EPMC10947466 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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A Domino Radical Amidation/Semipinacol Approach to All-Carbon Quaternary Centers Bearing an Aminomethyl Group.

Dhak Mandeep S MS   Arunprasath Dhanarajan D   Argent Stephen P SP   Cuthbertson James D JD  

Chemistry (Weinheim an der Bergstrasse, Germany) 20230724 47

A photoredox-mediated radical amidation ring-expansion sequence that enables the generation of all-carbon quaternary centers bearing a protected aminomethyl substituent is described. The methodology can be applied to both styrene and unactivated alkene substrates generating structurally diverse sp<sup>3</sup> -rich amine derivatives in a concise manner. ...[more]

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