Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia.

ABSTRACT: Microglia-mediated synaptic plasticity after CNS injury varies depending on injury severity, but the mechanisms that adjust synaptic plasticity according to injury differences are largely unknown. This study investigates differential actions of microglia on essential spinal motor synaptic circuits following different kinds of nerve injuries. Following nerve transection, microglia and C-C chemokine receptor type 2 signaling permanently remove Ia axons and synapses from the ventral horn, degrading proprioceptive feedback during motor actions and abolishing stretch reflexes. However, Ia synapses and reflexes recover after milder injuries (nerve crush). These different outcomes are related to the length of microglia activation, being longer after nerve cuts, with slower motor-axon regeneration

SUBMITTER: Rotterman TM 

PROVIDER: S-EPMC10947500 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature