A single base pair substitution in zebrafish distinguishes between innate and acute startle behavior regulation.

ABSTRACT: Behavioral thresholds define the lowest stimulus intensities sufficient to elicit a behavioral response. Establishment of baseline behavioral thresholds during development is critical for proper responses throughout the animal's life. Despite the relevance of such innate thresholds, the molecular mechanisms critical to establishing behavioral thresholds during development are not well understood. The acoustic startle response is a conserved behavior whose threshold is established during development yet is subsequently acutely regulated. We have previously identified a zebrafish mutant line (escapist) that displays a decreased baseline or innate acoustic startle threshold. Here, we identify a single base pair substitution on Chromosome 25 located within the coding sequence of the synaptotag

SUBMITTER: Ortiz EA 

PROVIDER: S-EPMC10947677 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature