Association of Vitamin E and Cognitive Decline in Older Adults with and without the APOEɛ4 Allele: A Biracial Population-Based Community Study.

ABSTRACT:

Background

The association of different types of tocopherols (vitamin E) with cognition might vary by the APOEɛ4 allele status.

Objective

We examined the association of dietary tocopherols with cognitive decline among participants with and without the APOEɛ4 allele over a median of 12 years.

Methods

2,193 participants from the Chicago Health and Aging Project were included in the analyses. Global cognition was assessed in three-year cycles. We used a 144-item FFQ to assess dietary intakes of tocopherols and hME Sequenom mass-array platform to assess APOE genotype. We used linear mixed effects models to examine the relationship between tocopherol from food sources and global cognitive decline.

Results

The mean baseline age was 74.1 (SD = 5.9) years. Among APOEɛ4

SUBMITTER: Liu X 

PROVIDER: S-EPMC10947793 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature