Clinical and neuroimaging risk factors associated with the development of intracerebral hemorrhage while taking direct oral anticoagulants.

ABSTRACT:

Background and aims

Intracerebral hemorrhage (ICH) associated with direct oral anticoagulant (DOAC) usage confers significant mortality/disability. We aimed to understand the clinical and neuroimaging features associated with developing ICH among DOAC users.

Methods

Clinical and radiological data were collected from consecutive DOAC users with ICH (DOAC-ICH) and age-matched controls without ICH from a single referral center. The frequency/distribution of MRI markers of hemorrhage risk were assessed. Baseline demographics and neuroimaging markers were compared in univariate tests. Significant associations (p < 0.1) were entered into a multivariable regression model to determine predictors of ICH.

Results

86 DOAC-ICH and 94 ICH-free patients were included. Diabetes, cor

SUBMITTER: Das AS 

PROVIDER: S-EPMC10947801 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature