Early-Onset Hearing Loss in Mouse Models of Alzheimer's Disease and Increased DNA Damage in the Cochlea.

ABSTRACT: There is considerable interest in whether sensory deficiency is associated with the development of Alzheimer's disease (AD). Notably, the relationship between hearing impairment and AD is of high relevance but still poorly understood. In this study, we found early-onset hearing loss in two AD mouse models, 3xTgAD and 3xTgAD/Polβ^+/-. The 3xTgAD/Polβ^+/- mouse is DNA repair deficient and has more humanized AD features than the 3xTgAD. Both AD mouse models showed increased auditory brainstem response (ABR) thresholds between 16 and 32 kHz at 4 weeks of age, much earlier than any AD cognitive and behavioral changes. The ABR thresholds were significantly higher in 3xTgAD/Polβ^+/- mice than in 3xTgAD mice at 16 kHz, and distortion product otoacoustic emission signa

SUBMITTER: Park JH 

PROVIDER: S-EPMC10948084 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature