Gut microbiota's causative relationship with peripheral artery disease: a Mendelian randomization study.

ABSTRACT:

Introduction

The relationship between gut microbiota and peripheral artery disease (PAD) remains understudied. While traditional risk factors like smoking and hyperlipidemia are well-understood, our study aims to determine the potential causative association of gut microbiota with PAD using Mendelian Randomization.

Methods

Data from the International MiBioGen Consortium and the FinnGen research project were used to study 211 bacterial taxa. Instrumental variables, comprising 2079 SNPs, were selected based on significance levels and linkage disequilibrium. Analyses were conducted utilizing the inverse-variance weighted (IVW) method and other statistical MR techniques to mitigate biases, processed in R (v4.3.1) with the TwosampleMR package.

Results

Three bacterial taxa,

SUBMITTER: Tian Y 

PROVIDER: S-EPMC10948605 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature